Our Treatment Outcomes in Patients with Acute Deep Vein Thrombosis Associated with Congenital Inferior Vena Cava Agenesis

Abstract

Introduction: In this study, we present the treatment outcomes of patients with acute deep venous thrombosis (DVT) associated with congenital agenesis of the inferior vena cava (IVCA).

Patients and Methods: In this retrospective study, the clinical findings and follow-up data of patients who were scheduled for an interventional procedure due to acute DVT in 2019-2021 and who were found to have IVCA in venography were analyzed retrospectively.

Results: A total of 11 patients with acute DVT associated with IVCA were identified during the study period. Eight of the patients (72.7%) were male. The mean age of the patients was 25.5 ± 6.5 years (16-36 years). Five of the patients were followed up with conservative medical treatment. Endovascular procedure was performed in six patients. At the end of the first year, moderate post-thrombotic syndrome was found in 1 patient and mild post-thrombotic syndrome was detected in 2 patients. Patients who received only medical treatment had a significantly higher Villalta score at the end of the first year than patients who received endovascular treatment (6.6 ± 4.1 and 2.1 ± 1.9, p= 0.04).

Conclusion: Congenital IVCA is a rare diagnosis that should be kept in mind in young patients with deep venous thrombosis. In these patients, endovascular approach may be effective to prevent postthrombotic syndrome.

The Institutional Ethical Committee of Bezmialem Vakif University approved the study protocol (Decision No: 2021/298, Date: 08.07.2021).

Informed consent was obtained.

Externally peer-reviewed.

Concept/Design - HE, ES; Analysis/Interpretation - HE, ES; Data Collection - ES; Writing - HE, ES; Critical Revision - HE, ES; Statistical Analysis - HE, ES; Overall Responsibility - HE, ES; Final Approval - All of authors.

The authors have no conflicts of interest to declare

The authors declared that this study has received no financial support.