Is There a Relationship Between the Arterial Stiffness and Effectiveness of Acetylsalicylic Acid in Patients with Stable Coronary Artery Disease?

Abstract

Introduction: We aimed to investigate whether arterial stiffness (AS) is associated with effectiveness of acetylsalicylic acid in patients with stable coronary artery disease. Patients and Methods: We enrolled 82 consecutive stable coronary artery disease patients taking at least one week acetylsalicylic acid. AS was evaluated by aortic pulse wave velocity (PWV) and augmentation index (AIx). These parameters were measured with Sphygmo- Cor device. Acetylsalicylic acid effi cacy was evaluated by serum thromboxane B2 (TxB2) level. Results: The mean age was 63 ± 9 years. Aortic PWV was 11.7 ± 2.8 (m/sec) and AIx was 28 ± 9 years (%), in the study group. Serum TxB2 level was 428 ± 1312 (mg/dL). There was no signifi cant correlation between serum TxB2 level and AS parameters. However, total cholesterol (r= 0.21, p= 0.05) and LDL cholesterol (r= 0.25, p= 0.02) levels were signifi cantly correlated with the serum levels of TxB2. Conclusion: The fi ndings of this study suggest that there is no relationship between AS and effi cacy of acetylsalicylic acid in patients with stable coronary artery disease.