Ümmü Tas, Sedat Taş, Efe Edem, Barış Ünal, Zülkif Tanrıverdi̇, Mustafa Türker Pabuccu, Muhammed Murat Necati Aksoy, Sabiye Yılmaz, Saadet Demi̇rtaş, Özhan Göldeli̇

Keywords: P-wave dispersion, thrombolytic therapy, STEMI, ST segment resolution


Introduction: The value of P-wave dispersion (PWD) on the surface electrocardiogram (ECG) has been shown to increase in coronary ischemia. Previous studies demonstrated that PWD decreased with repefusion therapy in patients with STEMI. The aim of current study is to investigate whether PWD is able to be used as an additional parameter to predict successful reperfusion and infarct related artery patency in patients with STEMI who were admitted in the first 12 hours of myocardial infarction and received thrombolytic therapy.Patients and Methods: A total of 150 patients who referred to Dokuz Eylül University Cardiology Department with STEMI between 01 January 2012 and 01 December 2013 and received thrombolytic therapy in the first 12 hours of the symptoms were included in our study. Hospital records of each patient were evaluated retrospectively. Demographical features were noted. Standart 12-lead surface ECG of each patient which were recorded before and at 30, 60, 90 and 120 minutes after the start of thrombolytic therapy were obtained. Maximum, minimum P-wave duration and PWD were calculated on each electrocardiogram and ST segment resolution was determined. Coronary angiography images were also evaluated to determine TIMI flow grade and TIMI frame count of the infarct related artery. The relationship between PWD and ST segment resolution and infarct related artery patency was investigated.Results: While PWD at the start of the thrombolytic therapy was 50.79±14.12 ms, PWD at 90th minute of thrombolytic therapy was calculated as 48.34±15.60 and PWD at 120th minute of thrombolytic therapy was calculated as 47.85±10.87 ms; the difference was not statistically significant (p= 0.07). The comparison of PWD values with ST segment resolution groups demonstrated that PWD at 120th minute of thrombolytic therapy was found to be significantly lower in complete resolution group than incomplete and inadequate resolution groups (42.10±9.55, 49.65±10.60, 56.08±7.44 ms respectively; p