Selahattin Akyol1, Hazar Harbalıoğlu2, Mustafa Gür3, Özcan Erel4, Hakim Çelik5

1Clinic of Cardiology, Kartal Koşuyolu High Specialization Training and Research Hospital, İstanbul, Türkiye
2Clinic of Cardiology, Akçakoca Public Hospital, Düzce, Türkiye
3Clinic of Cardiology, Adana Numune Training and Research Hospital, Adana, Türkiye
4Department of Biochemistry, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye
5Department of Biochemistry, Harran University Faculty of Medicine, Şanlıurfa, Türkiye

Keywords: Antioxidant; thiol


Introduction: The oxidized thiol/disulfide couple has been investigated and reported as a potential risk factor for cardiovascular diseases. Additionally, an increased pulse wave velocity has been identified as a predictor of cardiovascular events.

Patients and Methods: 262 patients were included in our study. Native and total thiol levels, total disulfide levels, disulfide per total thiol ratios, native thiol per total thiol ratios, and disulfide per native thiol level ratios were calculated.

Results: Patients were divided into Pulse Wave Velocity (PWV) low and PWV high groups. Native and total thiol levels were higher in PWV low group compared to PWV high group (p< 0.001 for both). The median disulfide value was higher in PWV high group (p= 0.002). Disulfide per native thiol and disulfide per total thiol ratio values were higher in PWV high group (p< 0.001). Native thiol per total thiol ratios were higher in the PWV-low group (p< 0.001).

Conclusion: The disulfide/native thiol pathway may be an indicator for predicting future atherosclerotic cardiovascular events.

Cite this article as: Akyol S, Harbalıoğlu H, Gür M, Erel Ö, Çelik H. Impact of disulfide/thiol redox couple on pulse wave velocity in patients with normal coronary angiography. Koşuyolu Heart J 2023;26(2):76-82.

Ethics Committee Approval

The approval for this study was obtained from Adana Numune Training and Research Hospital Non-invasive Clinical Research Ethics Committee (Decision no: 79, Date: 24.12.2014).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept/Design - SA; Analysis/Interpretation - MG, HÇ; Data Collection - SA, HH, ÖE; Writing - SA, HH; Critical Revision - HH, MG; Final Approval - All of authors; Statistical Analysis -MG; Overall Responsibility - SA.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declare that this study has received no financial support.