Serum Sodium Levels in Patients with ST-Segment Elevation Myocardial Infarction: Its Effects on In-Hospital and Long-Term Clinical Outcomes

Lütfi Öcal1, Aslı Öcal2, Sinan Cerşit1, Hayati Eren3, Ender Özgün Çakmak1, Hakan Çakır1

1Department of Cardiology, Kartal Kosuyolu High Specialization Training and Research Hospital, Istanbul, Turkey
2Department of Internal Medicine, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey
3Department of Cardiology, Elbistan State Hospital, Kahramanmaras, Turkey

Keywords: Sodium; myocardial infarction; mortality.

Abstract

Introduction: There are some conflicting results in the association of serum sodium level with clinical outcomes in patients with acute myocardial infarction. The aim of this study was to investigate the effect of serum sodium levels on in-hospital and long-term outcomes in patients with ST-segment elevation myocardial infarction (STEMI).

Patients and Methods: A total of 1840 patients with STEMI (mean age 57.3 ± 11.8; men 79.7%) who underwent primary percutaneous coronary intervention were included to the study. Baseline characteristics and outcomes were compared among the patients by admission serum sodium level and categorized accordingly; Q1, Q2, Q3 and Q4.

Results: There was not a significant difference regarding in-hospital mortality, cardiogenic shock, ventricular arrhythmia, acute kidney injury and major adverse cardiac events. Furthermore, after a follow-up period of 3-years; there was not a significant difference regarding long-term mortality and major adverse cardiac events.

Conclusion: In this large-scale study, we did not observe a significant association of serum sodium level with in-hospital and long-term clinical outcomes in patients with STEMI.

Ethics Committee Approval

The study was approved by the Kartal Dr. Lutfi Kirdar City Hospital Clinical Research Ethics Committee (Decision no: 514/196/5; Date: 24.02.2021).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept/Design - LÖ, AÖ; Analysis/Interpretation - SC, EÇ; Data Collection - LÖ, AÖ; Writing - SC, EÇ; Critical Revision - SC, EÇ; Statistical Analysis - HE, HÇ; Overall Responsibility - LÖ; Final Approval - All of authors.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.