Effects of Long-Term Fasting on Electrocardiographic Parameters
İstanbul Mehmet Akif Ersoy Göğüs, Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi, Kardiyoloji, İstanbul, Turkey
Keywords: fasting, electrocardiography, qrst angle
Objectives: In humans, long-term fasting reduces systemic inflammation and oxidative stress markers associated with atherosclerosis, and long-term fasting has been shown to have positive effects on cardiac functions. Frontal QRST angle (fQRSTa) is predictor of ventricular repolarization and is associated with arrhythmia incidence and adverse clinical outcomes. The aim of our study is to investigate the effect of long-term fasting periods on cardiac conduction system, ventricular functions and especially fQRSTa.
Patients and Methods: 57 volunteers who entered the long fasting period by fasting during the month of Ramadan were included in our study. Basal ECG records of patients before Ramadan were taken and control ECG records were examined after 1-month intermittent fasting periods. Basal and post-fasting ECG parameters and especially fQRSTa were compared. Ethical board validation is from İstanbul Mehmet Akif Ersoy Göğüs, Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi KAEK.
Results: In the long pre-fasting period, the QRS axis [38 (34.5-58), 56 (54-58); p <0.022] and P wave amplitude [0.040 (0.025-0.044), 0.046 (0.041-0.049); p = 0.001] was statistically lower than post-fasting period. T axis in the pre-fasting period [73 (56.5-83.5), 54 (47-57); p <0.001] and frontal QRS angle (33.4 ± 22.1, 12.4 ± 15.4; p <0.001) were statistically higher than the post-fasting period.
Conclusion: In this study, which examined the effect of long fasting on the heart conduction system and ventricular functions, an increase in P wave amplitude was observed in the post-fasting period. In addition, after fasting, increased in the QRS axis and decreased in the T axis result in decreased in fQRSTa. This can be evaluated as a positive effect on ventricular functions.