Heart Rate Variability in Patients with Chronic Obstructive Pulmonary Disease Treated by Noninvasive Mechanic Ventilation

Yusuf Karaveli̇oğlu, Hekim Karapınar, Zuhal Karakurt, Alim Erdem, Zekeriya Kaya, İbrahim Gül, Zekeriya Küçükdurmaz, Özlem Yazıcıoğlu Moçin, Cevat Kırma

Keywords: Chronic Obstructive Pulmonary Disease, Noninvasive Mechanic Ventilation, Heart Rate Variability.

Abstract

Aims: This study aimed to investigate heart rate variability (HRV) of patients with severe COPD who are treated by noninvasive mechanic ventilation (NIMV). Patients and Method: Twenty-seven patient (58±8 years, 9 F) with severe COPD treated by nocturnal NIMV at home and 23 sex and age matched volunteYusuf ers (56±8 years, 11 F) who has not dyspnea as a control group recruited in the study. Subjects underwent spirometry, blood gas analysis, transthoracic echocardiography, 24 hours ambulatory ECG analysis. Time domain HRV analysis performed from ambulatory ECG records. Results: 52% of patients at NYHA functional class II, 36% at class III, and 12% at class IV when they have been treated by NIMV. Groups were similar for age and sex (p>0.05 for both). Heart rates of patients were higher significantly than controls' (p0.05). But, systolic pulmonary pressures were higher of COPD group (p