Yusuf Karaveli̇oğlu, Hekim Karapınar, Zuhal Karakurt, Alim Erdem, Zekeriya Kaya, İbrahim Gül, Zekeriya Küçükdurmaz, Özlem Yazıcıoğlu Moçin, Cevat Kırma

Keywords: Chronic Obstructive Pulmonary Disease, Noninvasive Mechanic Ventilation, Heart Rate Variability.


Aims: This study aimed to investigate heart rate variability (HRV) of patients with severe COPD who are treated by noninvasive mechanic ventilation (NIMV). Patients and Method: Twenty-seven patient (58±8 years, 9 F) with severe COPD treated by nocturnal NIMV at home and 23 sex and age matched volunteYusuf ers (56±8 years, 11 F) who has not dyspnea as a control group recruited in the study. Subjects underwent spirometry, blood gas analysis, transthoracic echocardiography, 24 hours ambulatory ECG analysis. Time domain HRV analysis performed from ambulatory ECG records. Results: 52% of patients at NYHA functional class II, 36% at class III, and 12% at class IV when they have been treated by NIMV. Groups were similar for age and sex (p>0.05 for both). Heart rates of patients were higher significantly than controls' (p0.05). But, systolic pulmonary pressures were higher of COPD group (p