Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Mehmet Ata Akıl, Mehmet Zihni Bi̇li̇k, Halit Acet, Senem Yaman Tunç, Faruk Ertaş, Mesut Aydın, Hasan Kaya, Yahya İslamoğlu, Sait Alan

Keywords: Preeclampsia, mean platelet volume, neutrophil lymphocyte ratio, hypertension

Abstract

Introduction: This study was undertaken to examine the role of hematological parameters in predicting the severity of hypertension in pre-eclamptic women. Patients and Methods: Two hundred sixty-one pre-eclamptic women and fifty-one women with normal pregnancy were included in the study. The severity of preeclampsia was classified as mild or severe. Results: Compared to post-delivery period, pre-eclamptic females had lower platelet count, raised mean platelet volume and raised neutrophil lymphocyte ratio (p< 0.001, p< 0.001, p< 0.001, respectively). Multiple linear regression analysis showed an independent correlation between the severity of hypertension and mean platelet volume as well as the neutrophil lymphocyte ratio (β= 0.25, p< 0.001; β= 0.31, p< 0.001, respectively). Conclusion: Both mean platelet volume and neutrophil lymphocyte ratio emerged as independent predictors of the severity of hypertension in preeclampsia.