The Prognostic Value of the Monocyte/HDL Ratio in Predicting Short-term Mortality in Patients with Acute Pulmonary Embolism

Abstract

Introduction: Pulmonary embolism is an acute emergency with high mortality and morbidity rates. The monocyte/high-density lipoprotein (HDL) ratio was suggested as a new marker of inflammation and oxidative stress. In addition, the monocyte/HDL ratio has been shown to be closely related with the presence and prognosis of some cardiovascular diseases. Inflammation and oxidative stress play an important role in the pathophysiology of pulmonary embolism. The aim of the present study was to determine the prognostic value of the monocyte/HDL ratio in determining the short-term mortality for patients with acute pulmonary embolism. Patients and Methods: Ninety-nine patients who were admitted to the emergency department and diagnosed with acute pulmonary embolism, which was confirmed by multidetector computed tomography, were included in this retrospective study. Results: Of the 99 patients, 26 (25.2%) died within 1 month after the diagnosis was made. Patients were divided into two groups as survivors (group 1) and (group 2) within 1 month after diagnosis. Age; malignancy; coronary artery disease; right ventricular dysfunction; white blood cell, neutrophil, lymphocyte, platelet and monocyte counts; systolic pulmonary artery pressure, diastolic blood pressure, neutrophil/lymphocyte ratio, monocyte/HDL ratio and simplified pulmonary embolism severity index were significantly higher in group 1 (patients died within 1 month after diagnosis) than those in group 2. The monocyte/HDL ratio, neutrophil/lymphocyte ratio, right ventricle dysfunction and simplified pulmonary embolism severity index were independent predictors of mortality in patients with acute pulmonary embolism. Conclusion: The monocyte/HDL ratio, neutrophil/lymphocyte ratio, right ventricle dysfunction and simplified pulmonary embolism severity index were independent predictors of mortality in patients with acute pulmonary embolism.