Eyüp Özkan1, Ahmet Oğuz Baktır2, Erkan Demirci2, Hüseyin Odabaş3, Ahmet Tok4, Engin Dondurmacı5, Mehmet Uğurlu6

1Clinic of Cardiology, Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye
2Clinic of Cardiology, Kayseri City Hospital, Kayseri, Türkiye
3Clinic of Cardiology, Şanlıurfa Training and Research Hospital, Şanlıurfa, Türkiye
4Clinic of Cardiology, Bünyan District State Hospital, Kayseri, Türkiye
5Clinic of Cardiology, Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Türkiye
6Clinic of Cardiology, Bayındır İçerenköy Hospital, İstanbul, Türkiye

Keywords: RIMP; coronary dominance; FAC; GLS; STE; TAPSE


Introduction: The right heart is more unknown than the left heart, because of less research. With it, its importance is understood, when right heart related diseases are considered. The relation between coronary vascularity and cardiac function is indisputable. There are no research about the effect of coronary dominance, that is anatomical variation merely, upon cardiac function. We investigated difference of right or left domination on right ventricle functions using echocardiography.

Patients and Methods: Working group was contained patients who is done coronary angiography with any indication. Patients were categorized right dominant and non-dominant on coronary angiography. At the same time, the origin of posterior descending artery was determined. There were 2 groups and each of them had 40 patients. Patients who had >50% stenosis on coronary arteries, myocardial infarct previously, cardiac valve disease, chronic obstructive lung disease and pulmoner embolism in past were excluded. Right ventricle functions were investigated using Echocardiography by the same operator. The results were evaluated and calculated average value by two different operators. We used Wilcoxon and Mann-Whitney U Test in evaluation of statistics.

Results: There was no difference between groups in terms of the right ventricular functions; TAPSE (26.47 ± 3.39 vs 25.31 ± 5.19 p= 0.096), FAC (43.19 ± 9.18 vs 47.5 ± 10.7 p= 0.720), GLS by STE (20.55 ± 4.033 vs 19.73 ± 4.71 p= 0.451), RIMP (53.84 ± 11.2 vs 52.93 ± 9.01 p= 0.947).

Conclusion: The effect of right coronary artery dominance on right ventricle functions was not obtained significant.


The right ventricle (RV) is considered the neglected heart chamber due to inadequate research. It is speculated that the anatomy of the RV makes it less vulnerable to myocardial ischemia and protects it from being affected by myocardial and valvular diseases. Recent data suggested that several cardiac conditions have devastating effects on the function of the RV and this dysfunction has a severe prognostic impact. In practice, RV functions including abnormal filling and contraction may deteriorate in the absence of RV heart failure. Prior studies evaluating the RV were mainly focused on diseases that were known to affect RV functions including inferior myocardial infarction with RV involvement, chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH), and pulmonary hypertension secondary to chronic pulmonary thromboembolism (CTEPH).

There is solid evidence between impairment in coronary blood flow and myocardial functions. Ischemic cardiomyopathies are mainly caused by stenosis in coronary arteries leading to reversible or irreversible myocardial ischemia. In the present study, we aimed to compare the effect of right coronary artery (RCA) dominancy on RV functions in patients who do not have any diseases causing dysfunction in the RV such as coronary stenosis, COPD, PH, CTEPH, or valvular heart diseases.

Patients and Methods

Between December 2016 and May 2017, patients who underwent coronary angiography (CAG) and were found to have <50% stenosis in any coronary artery were divided into two groups according to the right coronary artery dominancy which was determined by the origin of the posterior descending artery (PDA)(1). It was considered right or non-right coronary arterydominant based on whether PDA originated from the RCA or not, respectively. Overall, 80 patients were included, and each group consisted of 40 patients.

The inclusion criteria were the following:

1) Undergoing CAG for the indications that were recommended in the latest guidelines,

2) Left ventricular ejection fraction (LVEF)> 50%,

3) Sinus rhythm in the baseline electrocardiography recording,

4) Absence of >50% stenosis in any coronary artery, and

5) Age between 18-80.

The exclusion criteria included the following:

1) Severe valvular heart disease,

2) Prior cardiac surgery,

3) Condition that may cause dysfunction in the RV including COPD, PH, and CTEPH,

4) Atrial fibrillation and

5) Prior myocardial infarction.

Patients underwent detailed physical examination and were probed for their medical histories.


The study population underwent echocardiographic evaluation by an experienced cardiac imager with an EPIQ 7C (EPIQ Evolution 2.0) echocardiography device. All cardiac chamber quantifications were determined according to the latest guidelines(2). RV basal, mid and apical diameters were measured at the end diastole in four chambers in the apical position. In the same window, systolic diameters were measured to calculate fractional area change (FAC). Tricuspid annular plane systolic excursion (TAPSE), isovolumetric relaxation time (IVRT), isovolumetric contraction time (IVCT), and ejection time (ET) were determined in accordance with the recent guidelines. Right ventricular myocardial perfusion index (RVMPI) was calculated as (IRT+ICT)/ET x 100.

RV global and free wall strains were obtained through apical four-chamber view and simultaneous ECG recording. RV Strain measurements were calculated with the modification of the left ventricular strain software as there is none for RV in our institution.

Statistical Analysis

Continuous variables were given as mean ± standard deviation, categorical variables were given as percentages. Intergroup differences were calculated by using Mann-Whitney U testing. P values of less than 0.05 were deemed statistically significant. All statistical analyses were made using SPSS for Windows, version 20.0, (SPSS Inc, Chicago, Illinois, USA).


Overall 134 patients were included in the study. Fourteen patients were excluded from the study because of COPD, 23 patients with previous CAD, 13 patients with AF, and four patients due to idiopathic CMP. Among those 40 patients had right dominancy and 40 had non-right dominancy. The mean age of patients were 51.56 ± 10.28 and 56.46 ± 9.73 in the right dominant and non-right dominant groups, respectively (p= 0.084). Baseline demographic characteristics of the patients are presented in Table 1. There were no significant differences among groups regarding hypertension (p= 0.862) and hyperlipidemia (p= 0.454) but there were more patients with diabetes in the non-right dominant group (p= 0.048).

There was no significant difference in global (20.55 ± 4.03 vs 19.73 ± 4.86, p= 0.451) and free wall (20.78 ± 4.54 vs 19.78 ± 4.71, p= 0.291) strain measurements between groups. Furthermore, there was no difference between groups in terms of TAPSE measurements (26.47 ± 3.39 vs 25.31 ± 5.19, p= 0.096).

Both groups were similar in terms of RVMPI (53.84 ± 11.2 vs 52.93 ± 9.0, p= 0.947), ET (242.28 ± 33.9 vs 237.11 ± 33.2, p= 0.163), IRT (62.44 ± 13.7 vs 65.76 ± 11.4, p= 0.313) and ICT (62.48 ± 13.6 vs 55.34 ± 15.4, p= 0.242).

No differences were found in RV inlet and outlet diameters. The mean end-diastolic and end-systolic areas were 14.37 ± 2.97 vs 14.76 ± 3.84 and 7.88 ± 2.49 vs 7.75 ± 2.69 in the right dominant and non-right dominant groups respectively. Therefore, there was no significant difference in FAD values between groups (46.19 ± 9.18 vs 47.5 ± 10.7, p= 0.720).

We performed S wave velocity with tissue Doppler. In the right-dominant group, TDI was 13.49 ± 2.76, while in the non-right-dominant group it was 15.13 ± 3.39 (p= 0.093). No significant difference was found in pulmonary artery diameter, and pulmonary valve velocity time index (VTI).


In the present study, we found no difference in RV systolic/diastolic functions, diameters, and strain parameters between patients who had right dominant or non-right dominant coronary vasculature. This is the first manuscript that evaluated the effect of coronary dominancy in RV functions in patients who had no disease that may cause RV dysfunction.

Previous studies mainly focused on the RV function in the context of diseases that involved RV such as RV myocardial infarction and PH. In the current manuscript, we evaluated only RCA dominancy on RV functions evaluated by echocardiography in the absence of any significant conditions affecting RV.

In a prior study, Blanchard DG, et al. included patients with CTEPH and compared the Tei index with those without CTEPH. They found higher Tei index those with CTEPH 0.27 ± 0.09 vs 0.52 ± 0.19, p= 0.0001)(3). When patients underwent pulmonary endarterectomy surgery, there was a significant reduction in Tei index (0.52 ± 0.19 vs 0.33 ± 0.10 (p< 0.0001). In previous studies, an increase in RVMPI was attributed to the conditions that caused an increase in the RV afterload and pulmonary vascular resistance(4,5). Accordingly, a prior study in which the Tei index was evaluated before and after the revascularization on days zero, seven and 30 revealed that RVMPI was correlated with ischemia severity and RV dysfunction(6). In this regard, no difference in RVMPI between the right-dominant and non-right-dominant groups was found in our study because we found no difference in pulmonary artery pressure, RV myocardial perfusion abnormality, and RV afterload.

We found no difference in terms of RV inlet and outlet diameters between groups. This finding is consistent with a prior study in which they included patients with myocardial infarction and RV involvement. In this study, Ramzy et al. compared RV planar diameters in patients with inferior myocardial infarction following thrombolytic therapy at discharge and day 30. They found that the RV inlet (4.0 ± 0.7 vs 3.7 ± 0.6 (p= 0.2) and outlet diameters (3.1 ± 0.3 vs 3.3 ± 0.6 (p= 0.2) were statistically similar between groups(6). Thus, right coronary artery dominancy was not expected to alter RV diameters as no difference was noted even in those with myocardial infarction.

Lemarie et al. investigated patients with anterior and inferior myocardial infarction and compared RV functions with cardiac magnetic resonance imaging (CMRI). Patients with RV EF <50% were considered to have RV involvement and these patients further underwent echocardiographic examination(7,8). They found that FAD (35.7 ± 11.0 vs 45.3 ± 8.7, p< 0.0001) and RV global strain determined by speckle tracking (17.1 ± 5.2 vs 21.0 ± 3.4, p< 0.0001). Segmental strain analysis revealed that all segments other than the septal segment were significantly correlated. There was no difference other than strain and FAD measurement which was consistent with our findings. This can be attributed to the absence of coronary lesions that can cause ventricular performance.

In CTEPH patients, a previous study investigated the correlation between right heart catheterization with TAPSE and RV longitudinal strain parameters. There was a significant correlation between TAPSE and RV longitudinal strain parameters. In addition, a trend toward a significant correlation was found between TAPSE with mean pulmonary artery pressure, pulmonary vascular resistance, right cardiac output, and cardiac index which did not reach statistical significance(9). In other studies of pulmonary arterial hypertension patients, deteriorated RV functions were observed despite normal TAPSE values(10). On the other hand, RV performance might be preserved even in patients with reduced TAPSE, as seen in patients undergoing cardiac surgery(11,12). In our study, we expected similar TAPSE as there was no underlying condition affecting RV cardiac index and output alteration.

Chang et al. included patients in which exercise intolerance was defined as effort capacity <8 MET and compared RV functions among those with exercise intolerance and those without. They found no significant difference except RV free wall strain measurements as consistent with our findings(13).

Apart from those studies, He, et al. followed 6255 patients who had acute coronary syndrome and underwent CAG for two years. Importantly, patients with left dominant coronary vasculature had a higher risk of mortality and intraaortic balloon pump requirement (2.58% vs 1.23%, p= 0.024)(14). Left ventricular coronary flow occurs mainly in the diastolic phase of the cardiac cycle. On the other hand, coronary flow to the thinwalled RV occurs both in the diastole and systole. We speculate that in the absence of any condition causing increased RCA vascular resistance, no difference in RV functions would be expected solely caused by RCA diameter ad length. Different findings might be expected if patients with RV hypertrophy deteriorating biphasic RV coronary perfusion were included.


This study had several limitations. First, this is a singlecenter and retrospective study with a limited number of patients. Second, echocardiographic strain measurements were performed according to the modified left ventricle strain settings. Third, myocardial ischemia was determined anatomically not functionally. Echocardiographic and angiographic evaluations were made by a single clinician. Therefore, it was not possible to provide an interobserver agreement.


Coronary artery dominancy in the absence of any other condition did not affect RV functions determined by echocardiographic examination.

Cite this article as: Özkan E, Baktır AO, Demirci E, Odabaş H, Tok A, Dondurmacı E, et al. The correlation between right ventricular function and dominance of right coronary artery. Koşuyolu Heart J 2022;25(2):208-212.

Ethics Committee Approval

The approval for this study was obtained from Erciyes University Clinical Research Ethics Committee (Decision no: 22017/105, Date: 17.02.2017).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept/Design - AOB; Analysis/Interpretation - MU; Data Collection - EÖ, ED; Writing - ED; Critical Revision - AT; Final Approval - AOB; Statistical Analysis - ED; Overall Responsibility - EÖ.

Conflict of Interest

The authors declared that there was no conflict of interest during the preparation and publication of this article.

Financial Disclosure

The authors declared that this study has received no financial support.


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