Reşit Coşkun1, Aziz İnan Çelik2, Muharrem Said Coşgun1, Cihat Dündar3, Murat Türkoğlu3, Halis Süleyman4

1Department of Cardiology, Erzincan Binali Yıldırım University Faculty of Medicine, Erzincan, Türkiye
2Clinic of Cardiology, Gebze Fatih State Hospital, Kocaeli, Türkiye
3B’iota R&D Center, İstanbul, Türkiye
4Department of Pharmacology, Erzincan Binali Yıldırım University Faculty of Medicine, Erzincan, Türkiye

Keywords: Doxorubicin; oxidative stress; cardiotoxicity; Phoenix Dactylifera L; rat


Introduction: Phoenix Dactylifera L (PDL) is a fruit containing a rich source of nutrients and bioactive molecules. Doxorubicin is a widely used agent, especially in the treatment of solid cancers. However, cardiotoxicity is one of its most challenging side effects. The present study aimed to investigate the preventive effect of PDL extract against doxorubicin-induced cardiotoxicity.

Patients and Methods: A total of 24 albino Wistar rats were divided into four equal groups. Phoenix Dactylifera L (PDLG) and Phoenix Dactylifera L + doxorubicin (PDXG) groups were strictly fed PDL for two weeks. The control group (CG) and the doxorubicin group (DOXG) were fed a standard diet. During this time, 5 mg/kg of doxorubicin was injected intraperitoneally to DOXG and PDXG once a day.

Results: Administration of doxorubicin to the DOXG significantly increased tissue oxidative stress parameters and caused the cardiac biomarker troponin-I (TP-I) to be released into the circulation; on the contrary, the levels of potent antioxidants such as total glutathione, superoxide dismutase, and catalase significantly decreased in DOXG compared to the other three groups. However, feeding purely with PDL decreased oxidative stress parameters and TP-I levels in PDXG animals, despite exposure to doxorubicin. Additionally, an excessive decrease of tissue antioxidants was prevented when compared to the DOXG. Histopathological damage signs, such as necrosis and hemorrhage, were severe in the DOXG. However, in the PDXG animals, feeding with PDL provided the integrity of the heart tissue structure.

Conclusion: PDL was able to improve the cardiotoxic consequences of doxorubicin biochemically and histopathologically, possibly due to its antioxidant properties.

Cite this article as: Coşkun R, Çelik Aİ, Coşgun MS, Dündar C, Türkoğlu M, Süleyman H. Phoenix dactylifera l. tree fruit exerts cardioprotective effect against doxorubicin-induced heart damage in rats via inhibition of oxidative stress. Koşuyolu Heart J 2022;25(2):193-199.

Ethics Committee Approval

The study was approved by Recep Tayyip Erdoğan University Medical Experimental Application and Research Center Local Animal Experimentation Ethics Committee (Decision no: 11, Date: 26.10.2017).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept/Design - RC, HS; Analysis/Interpretation - AİÇ, MSC; Data Collection - CD, AİÇ; Writing - RC, HS; Critical Revision - MT, HS; Statistical Analysis - RC, CD, MT; Final Approval - RC, MSC; Overall Responsibility - RC.

Conflict of Interest

The authors declared that there was no conflict of interest during the preparation and publication of this article.

Financial Disclosure

The authors declared that this study has received no financial support.