Mustafa Ozan Gürsoy, Mustafa Yıldız

Keywords: Thienopyridine, proton pump inhibitors, acute coronary syndrome, drug interactions


Patients with an established diagnosis of acute coronary syndrome (ACS) require dual antiplatelet therapy, which is most commonly composed of asetil salicylic acid and thienopyridines. This group of patients usually comprises older subjects with comorbid diseases and need gastric protection for potential gastrointestinal bleeding. At the time of admission in intensive cardiac care units, proton pump inhibitors (PPIs) are usually used for standard medical treatment. Several studies have evaluated the potential interaction between PPIs and thienopyridines; however, they have reported conflicting results. Some studies found increased cardiovascular risk after the use of PPIs, whereas others did not detect any clinically significant risk. The rational use of concomitant thienopyridines and PPIs should be decided after weighing their risks against their benefits. The use of latest PPIs such as pantoprazole seems to be safe in ACS patients. This study summarizes the well-known interaction of PPIs and thienopyridines in ACS patients on the basis of previous literature.