Plateletcrit and Platelet Distribution Width as Independent Predictors of Coronary Artery Ectasia
Hikmet Hamur, Kamuran Kalkan, Hakan Duman, Murtaza Emre Durakoğlugi̇l, Zafer Küçüksu, Sinan İnci̇, Erkan Yıldırım
Keywords: Coronary artery ectasia, coronary artery disease, mean platelet volume, platelet distribution width
Abstract
Introduction: Coronary artery ectasia (CAE) is characterised by an abnormal dilatation of the coronary arteries. Platelet volume indices, including the mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelet count, are indicators of platelet activation. In this study, we investigated platelet volume indices in patients with CAE. Patients and Methods: The study group included 51 patients (38 men; mean age: 52 ± 9.9 years) with isolated CAE and 50 individuals with normal coronary arteries (39 men; mean age: 54 ± 11.3 years). Admission platelet volume indices were measured as part of the automated complete blood count. Results: Platelet count, MPV, PCT and PDW were higher in CAE than in the control group (p< 0.05). Multivariate analysis revealed PDW (odds ratio: 0.22, 95% confidence interval: 0.06-0.73, p= 0.013) and PCT (odds ratio: 3.41, 95% confidence interval: 1.66-6.98, p≤ 0.001) as independent predictors of CAE. Conclusion: This study demonstrates that PCT and PDW are independent predictors of CAE.