Role of Platelet-Lymphocyte Ratio in Prediction of Long-Term Mortality in Patients with Type A Acute Aortic Dissection

Mehmet Mustafa Tabakcı, Anıl Avcı, Cüneyt Toprak, Göksel Açar, Abdulkadir Uslu, Uğur Arslantaş, Serdar Demi̇r, Deniz Günay, Elnur Ali̇zade, Mehmet Altuğ Tuncer, Mustafa Akçakoyun

Keywords: Aortic dissection, inflammation, thrombosis, mortality, platelet-lymphocyte ratio

Abstract

Introduction: Type A acute aortic dissection (AD) is a life-threatening vascular emergency because of its high morbidity and mortality. Inflammation and thrombosis have been showed to be associated with AD. The aim of the study was to investigate whether there is a relationship between the platelet-lymphocyte ratio (PLR), which is a thrombo-inflammatory marker, and long-term mortality in patients with acute AD who underwent surgical repair. Patients and Methods: In this single-centre retrospective study, data of 163 patients who were diagnosed with Stanford type A acute AD were recorded. The patients were divided into two groups, namely low and high PLR groups, according to the median value of PLR. In total, 81 patients had low PLR levels (≤ 115) and 82 patients had high PLR levels (> 115). Results: A long-term survey was found to be lesser in the high PLR group. Furthermore, a high PLR level was determined to be an independent predictor of long-term mortality in patients with type A acute AD (HR: 1.008; CI: 1.002-1.013; p= 0.007). Conclusion: PLR is a simple and in expensive indicator of thrombosis and inflammation. On admission, its elevated levels may be valuable in the prediction of long-term mortality and may be used as a helpful marker in the risk stratification of patients with type A acute AD.