Effects of Cardiopulmonary Bypass Operation on Circulating Levels of Adropin, Elabela, and Nitric Oxide Depending on the Time Intervals

Abstract

Introduction: Elabela and adropin (nitric oxide-mediated effects) are two new hormones that are synthesized in the heart and discovered in the last decade, which play a role in vascular system homeostasis. Therefore, the main aim of this study was to examine the changes of adropin, elabela, and nitric oxide in blood samples taken at various time intervals during a coronary artery bypass graft using cardiopulmonary bypass. Patients and Methods: This study included 20 healthy individuals and 15 patients undergoing cardiopulmonary bypass surgery. Blood samples were taken from patients who had cardiopulmonary bypass surgery before anesthesia induction (T1), before bypass (T2), before removing the cross-clamp (T3), at the intensive care unit (T4), and at postoperative 24 (T5), 48 (T6), and 72 hours (T7). A blood sample was taken once from the healthy volunteer control group. Blood adropin, elabela, and nitric oxide quantities were measured by ELISA. Results: When the control adropin and nitric oxide blood values were compared with the adropin and nitric oxide blood values obtained at T1, adropin and nitric oxide levels in the blood collected during the T1 time interval were significantly lower. Elabela and lactate levels in the blood at the T1 time interval were significantly higher. In the blood samples taken at postoperative 24 (T5), 48 (T6), and 72 hours (T7), both blood elabela and blood lactate began to decrease significantly. Conclusion: Significant changes in the amount of these molecules in blood samples taken at various time intervals during cardiopulmonary bypass operation are promising in the monitoring of coronary artery bypass surgery.