The Relationship between Aortic Clamping Time and Platelet-lymphocyte Ratio in Isolated Coronary Artery Bypass Surgery

Abstract

Objectives: This study aims to evaluate the relationship between aortic clamp duration acute coronary syndrome (ACS) and platelet-to-lymphocyte ratio (PLR) in patients undergoing isolated coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB).

Methods: This retrospective study included 96 patients who underwent elective isolated CABG at a single center between June 2021 and September 2023. Patients were divided into two groups according to median ACS: Group I (ACS <66.2 min, n=54) and Group II (ACS >66.2 min, n=42). Demographic data, pre-operative and 24-h post-operative platelet and lymphocyte counts, and operative details were recorded. PLR was calculated using the platelet/ lymphocyte formula. Statistical analyses were performed using IBM Statistical Packages for the Social Sciences 25.0.

Results: The mean ages of Group I and Group II were 63.6±8.8 and 66±8.9 years, respectively (p>0.05). There was no significant difference in pre- and post-operative PLR values between the groups (p>0.05). There was no correlation between post-operative PLR and the duration of CPB and ACS (p>0.05). However, there was a strong positive correlation between CPB and ACS durations (p<0.001).

Conclusion: The study revealed that there was no significant correlation between post-operative PLR and perioperative ACS and CPB durations. While post-operative PLR increased significantly in both groups, this increase was not associated with the duration of ACS or CPB. PLR may be a useful biomarker in determining inflammation and adverse outcomes in CABG, but larger-scale, randomized, prospective studies are needed to confirm these findings.

Cite This Article: Durmaz D, Gündöner S. The Relationship between Aortic Clamping Time and Platelet-lymphocyte Ratio in Isolated Coronary Artery Bypass Surgery. Koşuyolu Heart J 2024;27(3):126–130

The study was approved by the Bandirma Onyedi Eylül University Non-Interventional Research Ethics Committee (no: 2024- 135, date: 13/06/2024).

Externally peer-reviewed.

Concept – D.D.; Design – S.G.; Supervision – S.G.; Funding – D.D.; Materials – S.G.; Data collection and/or processing – D.D.; Data analysis and/or interpretation – S.G.; Literature search – D.D.; Writing – S.G.; Critical review – D.D.

All authors declared no conflict of interest.

No AI technologies utilized.

The authors declared that this study received no financial support.