Ersan Oflar1, İsmail Ünğan2, Cennet Yıldız1, Güngör İlayda Bostancı Alp1, Büşra Mavi1, Fatma Nihan Turhan Çağlar1, Demet Erciyes3, Alparslan Şahin1

1Clinic of Cardiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye
2Clinic of Cardiology, Yalova State Hospital, Yalova, Türkiye
3Department of Cardiology, Demiroğlu Science University Faculty of Medicine, İstanbul, Türkiye

Keywords: Triglyceride; glucose; index; coronary arteries; ectasia


Introduction: Coronary artery ectasia (CAE) refers to a 1.5 fold increase in coronary artery diameter compared to the normal segment. Although the underlying pathophysiological mechanism is not fully elucidated, coronary atherosclerosis is thought to play a role in more than half of the cases. Triglyceride glucose (TyG) index is an indicator of insulin resistance. In the present study, aimed to evaluated TyG index values in CAE cases and find if a predictive value of TyG index existed.

Patients and Methods: Sixty-one patients with CAE (study group) and 64 patients with normal coronary arteries (control group) were included in the study. TyG index was calculated as ln (fasting triglyceride × fasting glucose/2).

Results: There were no differences between the two groups with respect to age, sex, diabetes mellitus prevalence, and biochemical parameters including, white blood cell, platelet, lymphocyte, monocyte counts, hemoglobin, hematocrit, urea, glucose, total cholesterol, high density lipoprotein-cholesterol, triglyceride levels and TyG index value. Twenty-five patients (41.0%) had one-vessel involvement, 24 (39.3%) patients had twovessel involvement and 12 (19.7%) patients had three-vessel involvement. Right coronary artery was the most commonly affected vessel (11, 44%), followed by left anterior descending artery (8, 35%), left main coronary artery (4, 16%) and circumflex artery (1, 4%). TyG index was statistically significantly higher in patients who had two/three vessel involvement (8.80 ± 0.48 vs 9.14 ± 0.62, p= 0.027). TyG index had statistically significant correlation with the number of ectatic vessels (r= 0.275, p= 0.032). ROC curve analysis showed that TyG index was useful for the prediction of ectasia severity (AUC= 0.653, 95% CI= 0.515-0.792, p= 0.043). TyG index value of 9.16 had 41.7% sensitivity and 84% specificity for prediction of CAE severity.

Conclusion: TyG index, which is easily calculated from biochemical parameters, might be used for the assessment of CAE severity.

Cite this article as: Oflar E, Ünğan İ, Yıldız C, Bostancı Alp Gİ, Mavi B, Turhan Çağlar FN, et al. Triglycerideglucose index could be used to predict severity of coronary artery ectasia. Koşuyolu Heart J 2023;26(1):34-39.

Ethics Committee Approval

This study was approved by Bakırköy Dr. Sadi Konuk Research and Training Hospital Clinical Research Ethics Committee (Decision no: 2021-19-01, Date: 04.10.2021).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept/Design - EO, İU, CY, AŞ; Analysis/ Interpretation - CY, İBA, BM; Data Collection - EO, İU, AS; Writing - CY; Critical Revision - All of authors; Statistical Analysis - CY; Overall Responsibility - All of authors.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declare that this study has received no financial support.