Sacubitril/Valsartan Treatment in Heart Failure Increases The Left Ventricular Ejection Fraction: A Bayesian Analysis
Oğuzhan Birdal1, Mehmet Saygı2, Pınar Demir Gündoğmuş3, Emrah Aksakal4, Flora Özkalaycı2
1Department of Cardiology, Atatürk University Faculty of Medicine, Erzurum, Türkiye
2Clinic of Cardiology, Hisar Intercontinental Hospital, İstanbul, Türkiye
3Clinic of Cardiology, Kırıkkale Yüksek İhtisas Hospital, Kırıkkale, Türkiye
4Clinic of Cardiology, Erzurum City Hospital, Erzurum, Türkiye
Keywords: ARNI; bayesian; ejection fraction
Introduction: Heart failure is an important leading cause of mortality and morbidity despite optimal medical treatment and device therapy. Sacubitril/valsartan, a first-generation drug, was approved to use heart failure treatment recently. There are limited studies on the relationship between sacubitril/valsartan and left ventricular contraction. In our study, we aimed to evaluate the changes in left ventricular ejection fraction (LVEF) after sacubitril/valsartan treatment.
Patients and Methods: Fifty-two patients with heart failure and reduced ejection fraction (HFrEF) were enrolled in this study. The baseline demographic, clinical, and echocardiographic characteristics of 52 patients were compared using the Bayesian method.
Results: Fifty-two patients with heart failure and reduced ejection fraction (HFrEF) were included in the final analysis (66.2 ± 9.3 years, 69.2% male). Sacubitril/valsartan initial dose was low in 44.2% of patients, and intermediate in 55.8%. In the low initial dose population, the increase in absolute LVEF was 3.87 (95% HDI 1.53-6.20) and in the intermediate initial dose population, the increase in absolute LVEF was 5.89 (95% HDI 4.18-7.61). In the female population, the increase in absolute LVEF was 5.56 (95% HDI 3.49-7.63) and in the male population 4.75 (95% HDI 2.91-6.58) respectively.
Conclusion: In this study, we demonstrated that sacubitril/valsartan is associated with increased LVEF regardless of baseline clinical characteristics.
Cite this article as: Birdal O, Saygı M, Demir Gündoğmuş P, Aksakal E, Özkalaycı F. Sacubitril/valsartan treatment in heart failure increases the left ventricular ejection fraction: A bayesian analysis. Koşuyolu Heart J 2022;25(3):250-256.
The approval for this study was obtained from Erzurum Regional Training and Research Hospital Clinical Research Ethics Committee 'Decision no: 2022/06-59, Date: 16.05.2022).
This is retrospective study, we could not obtain written informed consent from the participants.
Concept/Design - OB, MS; Analysis/Interpre- tation - PDG, FÖ; Data Collection - OB, PDG, MS; Writing - OB, MS, EA; Critical Revision - EA; Final Approval - All of authors; Statistical Analysis - FÖ; Overall Responsibility - OB.
The authors have no conflicts of interest to declare.
The authors declare that this study has received no financial support.