Ulaş Serkan Topaloğlu

Kayseri City Training and Research Hospital, Clinic of Internal Diseases, Kayseri, Turkey

Keywords: C-Reactive protein; risk factors; metabolic syndrome; prediabetes


Introduction: Prediabetes, defined as high plasma glucose which is neither normoglycemic nor diabetic, is noteworthy in that it causes complications. We aimed to reveal cardiovascular risk factors and related parameters via comparing prediabetics with age, sex and body mass index-matched control group in this study.

Patients and Methods: The patients, aged 18-65 years, were recruited from a tertiary care hospital. A total of 74 patients with prediabetes were included into the study to be compared with the control group of 34 normoglycemic subjects. Laboratory parameters, health indicators, insulin resistance, SCORE and Framingham risk score of participants were measured for cardiovascular risk factors.

Results: Total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglycerides, insulin resistance, smoking status, blood pressure, SCORE, Framingham risk score, waist circumference, cardiovascular conditions (coronary artery disease, stroke, heart failure, hyperlipidemia, hypertension) were statistically similar between the two groups. Oral glucose tolerance tests (0th, 2nd), HbA1c and CRP were higher in the prediabetic group. Patients with prediabetes had more common participants with metabolic syndrome. When some outcomes affecting the presence of metabolic syndrome in participants with prediabetics were evaluated by regression analyses, obesity and HDL were found to be related factors. There was no correlation between C-reactive protein and any parameter.

Conclusion: We report that cardiovascular risk factors, which are often overrated in number-driven targets and evidence-based approach of the treatment of diabetes, may present in the prediabetic stage before the onset of diabetes. In addition, the parameters related to these factors and the relationship of prediabetes with metabolic syndrome were revealed.

Cite this article as: Topaloğlu US. Cardiovascular risk factors in patients with prediabetes and its relationship with metabolic syndrome. Koşuyolu Heart J 2020;23(3):196-202.