Does Monocyte/High-Density Lipoprotein Cholesterol Ratio Predict Saphenous Vein Graft Patency in Patients with Stable Angina Pectoris?

Abstract

Introduction: Circulating monocyte count is a predictive factor of new atherosclerotic plaque development. In addition, there is a strong inverse relationship between high-density lipoprotein (HDL) cholesterol and atherosclerosis. It has been shown that the monocyte/HDL cholesterol ratio (MHR) is a novel inflammatory marker. We aimed to investigate the relationship between MHR and saphenous vein graft disease (SVGD). Patients and Methods: A total of 3 69 patients were divided into 3 groups (positive SVGD group= 150, negative SVGD group= 89, normal coronary artery group= 130). Baseline characteristics and laboratory parameters were recorded and compared among the groups. Results: There were no significant differences between the positive and negative SVGD groups, except for age of SVG and left ventricular ejection fraction, according to baseline characteristics. C-reactive protein (CRP) levels, fasting blood glucose levels and mean platelet volume were higher in the positive SVGD group than in the negative SVGD group (p= 0.008, 0.048 and 0.042, respectively). MHR was not significantly different between the positive and negative SVGD groups (p= 0.169) and normal coronary artery group (p= 0.364). CRP was found to be an independent predictor factor of SVGD. Conclusion: There was no association between MHR and coronary atherosclerosis. MHR was not a predictive factor of SVGD.