Contrast-Induced Nephropathy: Management by Antioxidant Therapy

Mutlu Büyüklü, Eftal Murat Bakırcı, Hüsnü Deği̇rmenci̇, Gökhan Ceyhun, Ergün Topal

Keywords: Contrast, contrast-induced nephropathy, antioxidant treatment, angiography

Abstract

At present, the number of imaging and interventional procedures using contrast agents is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Despite the use of various prophylactic therapies and low-osmolar contrast agents with lesser adverse effects, intravenous isotonic fluid infusion is the only method that has been proven to be effective in preventing contrast-induced nephropathy in clinic practice. Therefore, a novel kidney-protecting treatment model is required for contrast-induced nephropathy.