Value of Alkaline Phosphatase in Predicting the Extent and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Abstract

Introduction: The serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor in stable coronary artery disease (CAD) and acute myocardial infarction (AMI) by its promoting effect on vascular calcification. The objectives of this study were to investigate serum ALP levels and to determine their value in predicting the extent and severity of CAD in patients with AMI. Patients and Methods: A total of 200 patients with AMI were included in this study. Patients with serum ALP levels higher than 120 mg/dL were classified as elevated ALP group. The extent and severity of CAD was assessed using Gensini score and number of vessel disease. Patients with a Gensini score greater than 40 were included in advanced CAD group. Results: There was no relationship between the ALP level and the Gensini score in study population. Patients were grouped according to the Gensini score (Gensini scores ≤ 40 and > 40). There was no difference between the groups in terms of ALP levels. However, ALP levels were significantly higher in diabetic patients and in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Parathormone levels and neutrophil counts were significantly higher in the advanced CAD group. Conclusion: ALP levels do not indicate the extent and severity of CAD in patients with AMI. However, these levels are higher in diabetic patients and in patients with NSTEMI than in patients with ST-segment elevation myocardial infarction. Higher parathormone levels and neutrophil counts are related to the extent and severity of CAD in patients with AMI.