Increased Remnant Cholesterol Blood Concentration Associated with First Acute Coronary Syndrome

Abstract

Introduction: This study aimed to investigate the association between remnant cholesterol and acute coronary syndrome (ACS) and its predictive value for acute coronary syndrome occurring for the first time. Patients and Methods: We compared increasing concentrations of non-fasting remnant cholesterol aside from other lipid profile parameters to investigate this association in 226 patients with ACS for the first time and 192 elective coronary angiography patients with normal coronary arteries. Results: Patients with ACS were mostly males and were younger than those in the control group; moreover, they had higher percentage of diabetes mellitus (for all p< 0.001). Glucose and white blood cell levels at admission were also higher in patients with ACS. Remnant cholesterol level (such as LDL-C) was statistically higher in the ACS group compared with those of the control group (p< 0.001). In the univariate and bivariate binary logistic regression analysis, high blood remnant cholesterol, high blood LDL-C, and low blood HDL-C levels had a predictive value for ACSs. Conclusion: This study demonstrated that remnant cholesterol levels (such as high blood LDL-C levels) are associated with increased risk of ACS for the first time. Further studies should be performed focusing on lowering remnant cholesterol levels apart from lowering LDL-C levels in patients with ACS.