Role of Mean Platelet Volume in the Development of Peripheral Artery Disease

Abstract

Introduction: The mean platelet volume (MPV) is one of several indicators of platelet activity. Recent studies have shown that MPV is increased in myocardial infarction, unstable angina, and stroke. Peripheral artery disease (PAD) manifests with the narrowing or obstruction of the abdominal aorta and arteries distal to the aortic bifurcation due to progressive atherosclerosis. The objective of this study is to investigate the MPV and platelet count in patients with PAD.

Patients and Methods: This study included 67 patients aged 40-80 years who underwent elective surgery for PAD in our hospital between January 2018 and June 2019, along with a control group comprising 67 patients without PAD. The MPV and platelet count values were obtained from a preoperatively performed hemogram analysis. Importantly, the groups were statistically compared in our study.

Results: As compared to the control group, the patients with PAD had a significantly higher mean age (p= 0.02), prevalence of diabetes mellitus (p< 0.01), as well as frequency of antiaggregant use (p< 0.01) and smoking (p< 0.01). There were no statistically significant differences in the other clinical features between the groups (p> 0.05). The mean platelet count and MPV were also significantly higher in patients with PAD as compared to patients without PAD (p< 0.01).

Conclusion: The use of inexpensive and widely used tests such as platelet count and MPV can facilitate an early diagnosis of the diseases with high morbidity and mortality, such as PAD.

This study was conducted in accordance with the Declaration of Helsinki after obtaining approval from the ethics committee of University of Health Sciences, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital (date: July 30, 2019; no: 2019-46).

Written informed consent was obtained from patients who participated in this study.

Externally peer-reviewed.

Concept/Design - DÖ, BB; Analysis/Interpretation - DÖ, BB; Data Collection - DÖ, BB; Writing - DÖ, BB, ÜA; Critical Revision -DÖ, BB, ÜA; Final Approval - DÖ, BB, ÜA; Statistical Analysis - DÖ, BB, ÜA; Obtained Funding - DÖ; Overall Responsibility - DÖ, BB, ÜA.

The authors have no conflict of interest to declare.

The authors declared that this study has received no financial support.